Recombinant human Platelet derived Growth Factor (PDGF-AA) protein (GF-080)

$150.00


Human PDGF-AA homodimer is produced by genetically engineered yeast, and purified by ionic exchange chromatography and reverse-phase HPLC. This polypeptide is composed of two identical polypeptide chains attached by disulfide bonds.
Alternative names PDGF A, PDGF A chain, PDGF subunit A, PDGF-1, PDGF1, PDGFA, PDGFA_HUMAN, Platelet derived growth factor alpha chain, Platelet derived growth factor alpha isoform 2 preproprotein, Platelet derived growth factor alpha polypeptide, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide, Platelet-derived growth factor subunit A
Type Recombinant.
Source Yeast


Description

Product name Recombinant human Platelet derived Growth Factor (PDGF-AA) protein (GF-080)
Catalog number GF-080-3
Brand family Austral Biologicals
Product type Proteins and Peptides


Biological Information

Purity Over 95% (N-terminal amino acid sequencing, amino acid composition, HPLC analysis, and SDS gel electrophoresis)
Purification method Ionic exchange chromatography and reverse-phase HPLC


Target

SwissProt ID Link P04085
Gene Aliases PDGFA, PDGF1
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB
Subcellular Location Secreted
Subunit Structure Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4
Sequence Similarities Belongs to the PDGF/VEGF growth factor family


Poduct Presentation

Form Lyophilized powder


Storage and Shipping Information

Storage Store at +4 ºC. Reconstitution is best in water or buffer near neutral pH


References and Citations

Citations 1. Heldin, C.H. and Westmark, B. (1990) Celll Regul. 1: 555-566
2. Raines, E. W. et al. (1990) Handbook of Experimental Pharmacology (Sporn, M.B. and Roberts, A.B. eds) Vol 9i5: pages 173-262
3. Ostman, A. et al. (1989) Growth Factors 1: 219-229