Natural Mouse Nerve Growth Factor (NGF) protein (GF-022)

$80.00


Mouse beta NGF is isolated from mouse submaxillary glands and purified by sequential ionic exchange and gel filtration chromatography.
Alternative names Beta nerve growth factor, Beta NGF, Beta-nerve growth factor, Beta-NGF, HSAN5, MGC161426, MGC161428, Nerve growth factor beta, Nerve growth factor beta polypeptide, Nerve growth factor beta subunit, NGF, NGF_HUMAN, NGFB, NID67
Type Natural.
Source Mouse submaxillary glands


Description

Product name Natural Mouse Nerve Growth Factor (NGF) protein (GF-022)
Catalog number GF-022-4
Brand family Austral Biologicals
Product type Proteins and Peptides


Biological Information

Purity Over 95% (N-terminal amino acid sequencing and SDS gel electrophoresis).
Purification method Purified by sequential chromatography.


Target

SwissProt ID Link P01138
Gene Aliases NGF, NGFB
Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI
Subcellular Location Secreted
Involvement in Disease A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable
Sequence Similarities Belongs to the NGF-beta family


Poduct Presentation

Form Lyophilized powder. This product should be centrifuged prior to use. Some of the product could be contained in the cap of the vial.


Storage and Shipping Information

Storage Store at +4 ºC. Reconstitution is best in water or acidic conditions.


References and Citations

Citations 1. Bradshaw, R.A., Blundell, T.L., Lapatto, R., McDonald, N.Q., and Murray-Rust, J. (1993) TIBS 18, 48-52
2. Drinkwater, C.C., Barker, P.A., Suter, U., and Shooter, E.M. (1993) The Journal of Biological Chemistry, Vol 268, No. 31, November, 23202- 23207
3. Ibanez, C.F. et al (1991. J. A. Neurochemistry, 57, 1033-1041