Recombinant mouse C-C Motif Chemokine 3 (MIP-1-alpha) protein (MI-270)


Mouse recombinant MIP-1-alpha is produced in genetically engineered yeast, and purified by sequential chromatography. This recombinant protein size is 7 kDa.
Alternative names C C motif chemokine 3, CCL 3, CCL3, CCL3_HUMAN, Chemokine C C motif ligand 3, G0/G1 switch regulatory protein 19 1, G0/G1 switch regulatory protein 19-1, G0S19 1, G0S19 1 protein, Heparin binding chemotaxis protein, L2G25B, LD78 alpha, LD78-alpha(4-69), LD78alpha, Macrophage inflammatory protein 1 alpha, Macrophage inflammatory protein 1-alpha, MIP 1 alpha, MIP 1A, MIP-1-alpha, MIP-1-alpha(4-69), MIP1A, PAT 464.1, SCYA 3, SCYA3, SIS alpha, SIS beta, SIS-beta, Small inducible cytokine A3, small inducible cytokine A3 (homologous to mouse Mip-1a), Small-inducible cytokine A3, Tonsillar lymphocyte LD78 alpha protein
Type Recombinant.
Source Yeast


Product name Recombinant mouse C-C Motif Chemokine 3 (MIP-1-alpha) protein (MI-270)
Catalog number MI-270-3
Brand family Austral Biologicals
Product type Proteins and Peptides

Biological Information

Purity Over 95% (SDS gel electrophoresis, with low level of endotoxin).
Concentration 1 mg/ml
Purification method Purified by sequential chromatography


SwissProt ID Link P10147
Gene Aliases CCL3, G0S19-1, MIP1A, SCYA3
Function Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)
Subcellular Location Secreted
Post-Translational Modification N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells
Subunit Structure Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69)
Sequence Similarities Belongs to the intercrine beta (chemokine CC) family

Poduct Presentation

Form Liquid solution
Preservative No preservatives added
Storage buffer DI water

Storage and Shipping Information

Storage Store at -80 ºC

References and Citations

Citations 1. Wolpe, S.D. et al. (1988) J. Exp. Med. 167:570.
2. Graham, G.J. et al. (1994) J. Biol. Chem. 269:4974.
3. Dexter, T.M. and White, H. (1990) Nature 344:380