Recombinant human Interleukin-6 (IL6) protein (CI-460-33)

$250.00


Human Interleukin-6 (IL-6) plays a role in the mediation of the inflammatory and immune response initiated by infection or injury. IL-6 acts on B cells by stimulating differentiation and antibody secretion. IL-6 also exhibits growth factor activity for mature thymic or peripheral T cells, and enhances the differentiation of cytotoxic T cells in the presence of IL-2 or IFNt. This glycoprotein is composed of 184 amino acid residues, and has a 42% homology with murine IL-6. Human Interleukin-6 (RECOMBINANT) is produced in genetically engineered Spodoptera frugiperda insect cells (Sf9) infected with recombinant viruses, and purified by sequential chromatography. This recombinant protein has a size of 20-21 kDa (glycoprotein).
Alternative names Interleukin BSF 2, B cell differentiation factor, B cell stimulatory factor 2, B-cell stimulatory factor 2, BSF 2, BSF-2, BSF2, CDF, CTL differentiation factor, Hepatocyte stimulatory factor, HGF, HSF, Hybridoma growth factor, Hybridoma growth factor Interferon beta-2, IFN-beta-2, IFNB2, IL 6, IL-6, IL6, IL6_HUMAN, Interferon beta 2, Interferon beta-2, Interleukin 6, Interleukin 6 (interferon beta 2), Interleukin BSF 2, Interleukin-6
Type Recombinant.
Source Sf9 Cells


Description

Product name Recombinant human Interleukin-6 (IL6) protein (CI-460-33)
Catalog number CI-460-33
Brand family Austral Biologicals
Product type Proteins and Peptides
Antibody Alternative Names Interleukin BSF 2
B cell differentiation factor
B cell stimulatory factor 2
B-cell stimulatory factor 2
BSF 2
BSF-2
BSF2
CDF
CTL differentiation factor
Hepatocyte stimulatory factor
HGF
HSF
Hybridoma growth factor
Hybridoma growth factor Interferon beta-2
IFN-beta-2
IFNB2
IL 6
IL-6
IL6
IL6_HUMAN
Interferon beta 2
Interferon beta-2
Interleukin 6
Interleukin 6 (interferon beta 2)
Interleukin BSF 2
Interleukin-6


Biological Information

Purity Over 85% (SDS gel electrophoresis). Contains < 1 ng/mg endotoxin.
Purification method Purified by sequential chromatography


Target

SwissProt ID Link P05231
Gene Aliases IL6, IFNB2
Function Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation
Subcellular Location Secreted
Involvement in Disease Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease description: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Post-Translational Modification N- and O-glycosylated
Sequence Similarities Belongs to the IL-6 superfamily


Poduct Presentation

Form Frozen liquid solution (PBS) at 0.50 mg/ml (50 µl/vial)


Storage and Shipping Information

Storage Store at -80 ºC


References and Citations

Citations 1. Taga, T., and Kishimoto, T., (1997) Ann. Rev. Immunology, 15, 797-819