Recombinant human Insulin-like Growth Factor-binding protein 2 (IGF-binding protein 2) (BP-350)


Human IGF-Binding protein 2 is produced in genetically engineered yeast, and purified by affinity chromatography and HPLC. This recombinant protein size is 31 kDa.
Alternative names BP 2, BP2, IBP 2, IBP-2, IBP2, IBP2_HUMAN, IGF binding protein 2, IGF BP53, IGF-binding protein 2, IGFBP 2, IGFBP-2, IGFBP2, IGFBP53, Insulin like growth factor binding protein 2, Insulin like growth factor binding protein 2 36kDa, Insulin like growth factor-binding protein 2 precursor, Insulin-like growth factor-binding protein 2
Type Recombinant.
Source Yeast


Product name Recombinant human Insulin-like Growth Factor-binding protein 2 (IGF-binding protein 2) (BP-350)
Catalog number BP-350-2
Brand family Austral Biologicals
Product type Proteins and Peptides

Biological Information

Purity Over 90% (SDS gel electrophoresis)
Purification method Purified by affinity chromatography and reverse-phase HPLC


SwissProt ID Link P18065
Gene Aliases BP2, IBP2
Function Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors
Subcellular Location Secreted
Post-Translational Modification O-glycosylated
Subunit Structure Binds IGF2 more than IGF1
Sequence Similarities Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain

Poduct Presentation

Form Lyophilized powder.

Storage and Shipping Information

Storage Store at +4 ºC. Reconstitution is best in water or buffer near neutral pH. After reconstitution, storage in aliquots at -80 ºC is recommended

References and Citations

Citations 1. Kiefer, M.C., Schmid, C., Waldvogel, M., Sclapfer, I., Futo, E., Maziarz, F.R., Green, K., Barr, P.J. and Zapf, J. (1992) The Journal of Biological Chemistry, Vol 267, No 18, 12692-12699.
2. Rechler M.M. and Brown A.L. (1992) Growth Regulation, 2, 55.
3. Modern Concepts of Insulin-Like Growth Factor. Ed. E. Martin Spencer, M.D. (1991). Elsevier Science Publ., pages 311-415