Recombinant human Beta-Nerve Growth Factor (NGF) protein (GF-340)

$150.00


Human recombinant Beta-NGF is purified from recombinant CHO cells and purified by sequential chromatography.
Alternative names Beta nerve growth factor, Beta NGF, Beta-nerve growth factor, Beta-NGF, HSAN5, MGC161426, MGC161428, Nerve growth factor beta, Nerve growth factor beta polypeptide, Nerve growth factor beta subunit, NGF, NGF_HUMAN, NGFB, NID67
Type Recombinant.
Source CHO Cells


Description

Product name Recombinant human Beta-Nerve Growth Factor (NGF) protein (GF-340)
Catalog number GF-340-4
Brand family Austral Biologicals
Product type Proteins and Peptides


Biological Information

Purity Over 90% (N-terminal amino acid sequencing and SDS gel electrophoresis - one major band at 14 KDa)
Purification method Purified by sequential chromatography


Target

SwissProt ID Link P01138
Gene Aliases NGF, NGFB
Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI
Subcellular Location Secreted
Involvement in Disease Neuropathy, hereditary sensory and autonomic, 5 (HSAN5)
The disease is caused by mutations affecting the gene. A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable
Subunit Structure Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner
Sequence Similarities Belongs to the NGF-beta family


Poduct Presentation

Form Lyophilized powder. This product should be centrifuged prior to use. Some of the product could be contained in the cap of the vial


Storage and Shipping Information

Storage Store at +4 ºC. Reconstitution is best in water or acidic conditions


References and Citations

Citations 1. Ibanez, C.F., Hallbook, F., Soderstrom, S., Ebendal, T., and Persson, H. (1991. Journal of Neurochemistry, Vol 57, No. 3, 1033-1041.
2. Marco, E.D., Mathor, M., Bondanza, S., Cutuli, P., Marchisio, P.C., Cancedda, R., and De Luca, M. (1993) The Journal of Bilogical Chemistry, Vol 268, No. 30, October, 22838-22846