Anti-BAIAP2 antibody (AA27314)

$187.00


Alternative names Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI-associated protein 2, BAI1-associated protein 2, Protein BAP2, Fas ligand-associated factor 3, FLAF3, Insulin receptor substrate p53/p58, IRS-58, IRSp53/58, Insulin receptor substrate protein of 53 kDa, IRSp53, Insulin receptor substrate p53, BAIAP2, BAIP2_HUMAN, Q9UQB8, 10458
Source 521
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-BAIAP2 antibody (AA27314)
Catalog number AA27314
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Brain-specific angiogenesis inhibitor 1-associated protein 2 antibody, BAI-associated protein 2 antibody, BAI1-associated protein 2 antibody, Protein BAP2 antibody, Fas ligand-associated factor 3 antibody, FLAF3 antibody, Insulin receptor substrate p53/p58 antibody, IRS-58 antibody, IRSp53/58 antibody, Insulin receptor substrate protein of 53 kDa antibody, IRSp53 antibody, Insulin receptor substrate p53 antibody, BAIAP2 antibody, BAIP2_HUMAN antibody


Biological Information

Concentration 1 mg/ml
Isotype IgG
Purification method Purified by affinity chromatography


Target

Target Name BAIAP2
SwissProt ID Link Q9UQB8
Function Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Subcellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Post-Translational Modification Phosphorylated on tyrosine residues by INSR in response to insulin treatment.
Tissue Specificity Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.
Subunit Structure Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1. Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Interacts with E.coli intimin receptor Tir.
Sequence Similarities Contains 1 IMD (IRSp53/MIM homology) domain. Contains 1 SH3 domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 C. Avoid multiple freeze/thaw cycles.