Anti-BAG3 antibody (AA39753)

$287.00


Alternative names BAG family molecular chaperone regulator 3, BAG-3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1, BAG3, BIS, BAG3_HUMAN, O95817, 9531
Source 575
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IP, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-BAG3 antibody (AA39753)
Catalog number AA39753
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names BAG family molecular chaperone regulator 3 antibody, BAG-3 antibody, Bcl-2-associated athanogene 3 antibody, Bcl-2-binding protein Bis antibody, Docking protein CAIR-1 antibody, BAG3 antibody, BIS antibody, BAG3_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human BAG3
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:20 - 1:200 IF 1:10 - 1:100 IP 1:20 - 1:50
Purification method Purified by affinity chromatography


Target

Target Name BAG3
SwissProt ID Link O95817
Function Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
Involvement in Disease Myopathy, myofibrillar, 6: A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. The disease is caused by mutations affecting the gene represented in this entry. Cardiomyopathy, dilated 1HH: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. The disease is caused by mutations affecting the gene represented in this entry.
Subunit Structure Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma. Interacts with DNAJB6.
Sequence Similarities Contains 1 BAG domain. Contains 2 WW domains.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.