Anti-BACE2 antibody (AA32276)

$287.00


Alternative names Beta-secretase 2, EC 3.4.23.45, Aspartic-like protease 56 kDa, Aspartyl protease 1, ASP1, Asp 1, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, Down region aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, BACE2, AEPLC, ALP56, ASP21, CDA13, UNQ418/PRO852, BACE2_HUMAN, Q9Y5Z0, 25825
Source 518
Species Reactivity Human, Mouse, Rat
Applications WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-BACE2 antibody (AA32276)
Catalog number AA32276
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Beta-secretase 2 antibody, EC 3.4.23.45 antibody, Aspartic-like protease 56 kDa antibody, Aspartyl protease 1 antibody, ASP1 antibody, Asp 1 antibody, Beta-site amyloid precursor protein cleaving enzyme 2 antibody, Beta-site APP cleaving enzyme 2 antibody, Down region aspartic protease antibody, DRAP antibody, Memapsin-1 antibody, Membrane-associated aspartic protease 1 antibody, Theta-secretase antibody, BACE2 antibody, AEPLC antibody, ALP56 antibody, ASP21 antibody, CDA13 antibody, UNQ418/PRO852 antibody, BACE2_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human BACE2
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200-1:2000
Purification method Purified by affinity chromatography


Target

Target Name BACE2
SwissProt ID Link Q9Y5Z0
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Subcellular Location Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
Post-Translational Modification Undergoes autoproteolytic cleavage.Glycosylated.
Tissue Specificity Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Subunit Structure Monomer. Interacts ith RTN3 and RTN4.
Sequence Similarities Belongs to the peptidase A1 family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.