Anti-BACE1 antibody (AA39228)

$287.00


Alternative names Beta-secretase 1, EC 3.4.23.46, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, BACE, KIAA1149, BACE1_HUMAN, P56817, 23621
Source 501
Species Reactivity Human, Mouse, Rat
Applications IP, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-BACE1 antibody (AA39228)
Catalog number AA39228
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Beta-secretase 1 antibody, EC 3.4.23.46 antibody, Aspartyl protease 2 antibody, ASP2 antibody, Asp 2 antibody, Beta-site amyloid precursor protein cleaving enzyme 1 antibody, Beta-site APP cleaving enzyme 1 antibody, Memapsin-2 antibody, Membrane-associated aspartic protease 2 antibody, BACE1 antibody, BACE antibody, KIAA1149 antibody, BACE1_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human BACE1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200 - 1:2000 IHC 1:50 - 1:200 IP 1:20 - 1:50
Purification method Purified by affinity chromatography


Target

Target Name BACE1
SwissProt ID Link P56817
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Subcellular Location Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane. Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
Post-Translational Modification N-Glycosylated. Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300 and Lys-307. Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein.
Tissue Specificity Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
Subunit Structure Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4. Interacts with SNX6. Interacts with PCSK9. Interacts with NAT8 and NAT8B.
Sequence Similarities Belongs to the peptidase A1 family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.