Anti-ATRIP antibody (AA38972)

$187.00


Alternative names ATR-interacting protein, ATM and Rad3-related-interacting protein, ATRIP, AGS1, ATRIP_HUMAN, Q8WXE1, 84126
Source 791
Species Reactivity Human
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ATRIP antibody (AA38972)
Catalog number AA38972
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names ATR-interacting protein antibody, ATM and Rad3-related-interacting protein antibody, ATRIP antibody, AGS1 antibody, ATRIP_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ATRIP
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Purification method Purified by affinity chromatography


Target

Target Name ATRIP
SwissProt ID Link Q8WXE1
Function Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
Subcellular Location Nucleus. Redistributes to discrete nuclear foci upon DNA damage.
Post-Translational Modification Phosphorylated by ATR.
Tissue Specificity Ubiquitous.
Subunit Structure Interacts with ATR. Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single-stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.
Sequence Similarities Belongs to the ATRIP family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.