Anti-ATP11B antibody (AA32126)

$287.00


Alternative names Probable phospholipid-transporting ATPase IF, EC 3.6.3.1, ATPase IR, ATPase class VI type 11B, P4-ATPase flippase complex alpha subunit ATP11B, ATP11B, ATPIF, ATPIR, KIAA0956, AT11B_HUMAN, Q9Y2G3, 23200
Source 1177
Species Reactivity Human, Mouse, Rat
Applications IHC
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ATP11B antibody (AA32126)
Catalog number AA32126
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Probable phospholipid-transporting ATPase IF antibody, EC 3.6.3.1 antibody, ATPase IR antibody, ATPase class VI type 11B antibody, P4-ATPase flippase complex alpha subunit ATP11B antibody, ATP11B antibody, ATPIF antibody, ATPIR antibody, KIAA0956 antibody, AT11B_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ATP11B
Concentration 1 mg/ml
Isotype IgG
Application Notes IHC 1:50-1:200
Purification method Purified by affinity chromatography


Target

Target Name ATP11B
SwissProt ID Link Q9Y2G3
Function Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.
Subcellular Location Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Golgi apparatus, trans-Golgi network. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, mainly located in recycling endosomes.
Subunit Structure Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.
Sequence Similarities Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.