Anti-ATL3 antibody (AA32291)

$287.00


Alternative names Atlastin-3, EC 3.6.5.-, ATL3, ATLA3_HUMAN, Q6DD88, 25923
Source 541
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ATL3 antibody (AA32291)
Catalog number AA32291
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Atlastin-3 antibody, EC 3.6.5.- antibody, ATL3 antibody, ATLA3_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ATL3
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500-1:2000 IF 1:50-1:100
Purification method Purified by affinity chromatography


Target

Target Name ATL3
SwissProt ID Link Q6DD88
Function GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network.
Involvement in Disease Neuropathy, hereditary sensory, 1F: An autosomal dominant sensory neuropathy affecting the lower limbs. Distal sensory impairment becomes apparent during the second or third decade of life, resulting in painless ulceration of the feet with poor healing, which can progress to osteomyelitis, bone destruction, and amputation. There is no autonomic involvement, spasticity, or cognitive impairment. The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in the central nervous system and in dorsal root ganglia neurons. Expressed in peripheral tissues (at protein level).
Sequence Similarities Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.