Anti-ATG4C antibody (AA39698)

$187.00


Alternative names Cysteine protease ATG4C, EC 3.4.22.-, AUT-like 3 cysteine endopeptidase, Autophagin-3, Autophagy-related cysteine endopeptidase 3, Autophagy-related protein 4 homolog C, ATG4C, APG4C, AUTL1, AUTL3, ATG4C_HUMAN, Q96DT6, 84938
Source 458
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ATG4C antibody (AA39698)
Catalog number AA39698
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Cysteine protease ATG4C antibody, EC 3.4.22.- antibody, AUT-like 3 cysteine endopeptidase antibody, Autophagin-3 antibody, Autophagy-related cysteine endopeptidase 3 antibody, Autophagy-related protein 4 homolog C antibody, ATG4C antibody, APG4C antibody, AUTL1 antibody, AUTL3 antibody, ATG4C_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ATG4C
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ATG4C
SwissProt ID Link Q96DT6
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Subcellular Location Cytoplasm.
Tissue Specificity Highly expressed in skeletal muscle, heart, liver and testis.
Sequence Similarities Belongs to the peptidase C54 family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.