Anti-ATG4B antibody (AA32123)

$287.00


Alternative names Cysteine protease ATG4B, EC 3.4.22.-, AUT-like 1 cysteine endopeptidase, Autophagin-1, Autophagy-related cysteine endopeptidase 1, Autophagy-related protein 4 homolog B, hAPG4B, ATG4B, APG4B, AUTL1, KIAA0943, ATG4B_HUMAN, Q9Y4P1, 23192
Source 393
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ATG4B antibody (AA32123)
Catalog number AA32123
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Cysteine protease ATG4B antibody, EC 3.4.22.- antibody, AUT-like 1 cysteine endopeptidase antibody, Autophagin-1 antibody, Autophagy-related cysteine endopeptidase 1 antibody, Autophagy-related protein 4 homolog B antibody, hAPG4B antibody, ATG4B antibody, APG4B antibody, AUTL1 antibody, KIAA0943 antibody, ATG4B_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ATG4B
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200-1:2000 IHC 1:50-1:200
Purification method Purified by affinity chromatography


Target

Target Name ATG4B
SwissProt ID Link Q9Y4P1
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Subcellular Location Cytoplasm.
Tissue Specificity Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.
Sequence Similarities Belongs to the peptidase C54 family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.