Anti-ATF3 antibody (AA25205)

$187.00


Alternative names Cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3, Activating transcription factor 3, ATF3, ATF3_HUMAN, P18847, 467
Source 181
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ATF3 antibody (AA25205)
Catalog number AA25205
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Cyclic AMP-dependent transcription factor ATF-3 antibody, cAMP-dependent transcription factor ATF-3 antibody, Activating transcription factor 3 antibody, ATF3 antibody, ATF3_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ATF3
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ATF3
SwissProt ID Link P18847
Function This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Subcellular Location Nucleus.
Subunit Structure Binds DNA as a homodimer or a heterodimer.
Sequence Similarities Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP (basic-leucine zipper) domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.