Anti-ASZ1 antibody (AA29405)

$287.00


Alternative names Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1, Ankyrin-like protein 1, Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein, ASZ1, ALP1, ANKL1, C7orf7, GASZ, ASZ1_HUMAN, Q8WWH4, 136991
Source 475
Species Reactivity Human, Mouse, Rat
Applications WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ASZ1 antibody (AA29405)
Catalog number AA29405
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 antibody, Ankyrin-like protein 1 antibody, Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein antibody, ASZ1 antibody, ALP1 antibody, ANKL1 antibody, C7orf7 antibody, GASZ antibody, ASZ1_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ASZ1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000
Purification method Purified by affinity chromatography


Target

Target Name ASZ1
SwissProt ID Link Q8WWH4
Function Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.
Subcellular Location Cytoplasm. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs.
Tissue Specificity Expressed exclusively in the testis and ovary and at higher levels in the adult testis compared with the adult ovary.
Subunit Structure Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
Sequence Similarities Contains 6 ANK repeats. Contains 1 SAM (sterile alpha motif) domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.