Anti-ASPSCR1 antibody (AA39942)

$187.00


Alternative names Tether containing UBX domain for GLUT4, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, Renal papillary cell carcinoma protein 17, UBX domain-containing protein 9, ASPSCR1, ASPL, RCC17, TUG, UBXD9, UBXN9, ASPC1_HUMAN
Species Reactivity Human
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ASPSCR1 antibody (AA39942)
Catalog number AA39942
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Tether containing UBX domain for GLUT4 antibody, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein antibody, Alveolar soft part sarcoma locus antibody, Renal papillary cell carcinoma protein 17 antibody, UBX domain-containing protein 9 antibody, ASPSCR1 antibody, ASPL antibody, RCC17 antibody, TUG antibody, UBXD9 antibody, UBXN9 antibody, ASPC1_HUMAN antibody


Biological Information

Concentration 1 mg/ml
Isotype IgG
Purification method Purified by affinity chromatography


Target

Target Name ASPSCR1
SwissProt ID Link Q9BZE9
Function Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Enhances VCP methylation catalyzed by VCPKMT.
Subcellular Location Endomembrane system; Peripheral membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Cytoplasm. Nucleus.
Involvement in Disease A chromosomal aberration involving ASPSCR1 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein. A chromosomal aberration involving ASPSCR1 has been found in two patients with of papillary renal cell carcinoma. Translocation t(X;17)(p11.2;q25).
Tissue Specificity Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.
Subunit Structure Interacts with GLUT4. Interacts with VCPKMT. Interacts with VCP.
Sequence Similarities Contains 1 UBX domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.