Anti-ASNA1 antibody (AA29942)

$287.00


Alternative names ATPase ASNA1, EC 3.6.-.-, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Transmembrane domain recognition complex 40 kDa ATPase subunit, hARSA-I, hASNA-I, ASNA1, ARSA, TRC40, ASNA_HUMAN, O43681, 439
Source 348
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ASNA1 antibody (AA29942)
Catalog number AA29942
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names ATPase ASNA1 antibody, EC 3.6.-.- antibody, Arsenical pump-driving ATPase antibody, Arsenite-stimulated ATPase antibody, Transmembrane domain recognition complex 40 kDa ATPase subunit antibody, hARSA-I antibody, hASNA-I antibody, ASNA1 antibody, ARSA antibody, TRC40 antibody, ASNA_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ASNA1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200-1:2000 IHC 1:50-1:200 IF 1:50-1:100
Purification method Purified by affinity chromatography


Target

Target Name ASNA1
SwissProt ID Link O43681
Function ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling.
Subcellular Location Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
Tissue Specificity Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle.
Subunit Structure Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
Sequence Similarities Belongs to the arsA ATPase family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.