Anti-ASIP antibody (AA38171)

$187.00


Alternative names Agouti-signaling protein, ASP, Agouti switch protein, ASIP, AGTI, AGTIL, ASIP_HUMAN, P42127, 434
Source 132
Species Reactivity Human
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ASIP antibody (AA38171)
Catalog number AA38171
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Agouti-signaling protein antibody, ASP antibody, Agouti switch protein antibody, ASIP antibody, AGTI antibody, AGTIL antibody, ASIP_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ASIP
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Purification method Purified by affinity chromatography


Target

Target Name ASIP
SwissProt ID Link P42127
Function Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Subcellular Location Secreted.
Tissue Specificity Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
Sequence Similarities Contains 1 agouti domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.