Anti-ASGR1 antibody (AA38168)

$187.00


Alternative names Asialoglycoprotein receptor 1, ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1, ASGR1, CLEC4H1, ASGR1_HUMAN
Species Reactivity Human
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ASGR1 antibody (AA38168)
Catalog number AA38168
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Asialoglycoprotein receptor 1 antibody, ASGP-R 1 antibody, ASGPR 1 antibody, C-type lectin domain family 4 member H1 antibody, Hepatic lectin H1 antibody, HL-1 antibody, ASGR1 antibody, CLEC4H1 antibody, ASGR1_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ASGR1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ASGR1
SwissProt ID Link P07306
Function Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Subcellular Location Isoform H1a: Membrane; Single-pass type II membrane protein.; Isoform H1b: Secreted.
Post-Translational Modification Phosphorylated on a cytoplasmic Ser residue.
Tissue Specificity Expressed exclusively in hepatic parenchymal cells.
Subunit Structure Interacts with LASS2.
Sequence Similarities Contains 1 C-type lectin domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.