Anti-ARNT antibody (AA23264)

$187.00


Alternative names Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta, ARNT, ARNT_HUMAN
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Conjugated Unconjugated


Description

Product name Anti-ARNT antibody (AA23264)
Catalog number AA23264
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Aryl hydrocarbon receptor nuclear translocator antibody, ARNT protein antibody, Class E basic helix-loop-helix protein 2 antibody, bHLHe2 antibody, Dioxin receptor, nuclear translocator antibody, Hypoxia-inducible factor 1-beta antibody, HIF-1-beta antibody, HIF1-beta antibody, ARNT antibody, ARNT_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ARNT
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ARNT
SwissProt ID Link P27540
Function Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
Subcellular Location Nucleus.
Subunit Structure Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3. Interacts with NOCA7. Heterodimer with HIF1A.
Sequence Similarities Contains 1 bHLH (basic helix-loop-helix) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.