Anti-ARNT2 antibody (AA31634)

$287.00


Alternative names Aryl hydrocarbon receptor nuclear translocator 2, ARNT protein 2, Class E basic helix-loop-helix protein 1, bHLHe1, ARNT2, KIAA0307, ARNT2_HUMAN, Q9HBZ2, 9915
Source 717
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ARNT2 antibody (AA31634)
Catalog number AA31634
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Aryl hydrocarbon receptor nuclear translocator 2 antibody, ARNT protein 2 antibody, Class E basic helix-loop-helix protein 1 antibody, bHLHe1 antibody, ARNT2 antibody, KIAA0307 antibody, ARNT2_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ARNT2
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200-1:2000 IHC 1:50-1:200
Purification method Purified by affinity chromatography


Target

Target Name ARNT2
SwissProt ID Link Q9HBZ2
Function Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE).
Subcellular Location Nucleus.
Involvement in Disease Webb-Dattani syndrome: A disorder characterized by postnatal microcephaly with fronto-temporal lobe hypoplasia, multiple pituitary hormone deficiency, global developmental delay, seizures, severe visual impairment and abnormalities of the kidneys and urinary tract. The disease is caused by mutations affecting the gene represented in this entry.
Subunit Structure Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein. Interacts with TACC3.
Sequence Similarities Contains 1 bHLH (basic helix-loop-helix) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.