Anti-ARL1 antibody (AA29927)

$287.00


Alternative names ADP-ribosylation factor-like protein 1, ARL1, ARL1_HUMAN, P40616, 400
Source 181
Species Reactivity Human, Mouse, Rat
Applications WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ARL1 antibody (AA29927)
Catalog number AA29927
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names ADP-ribosylation factor-like protein 1 antibody, ARL1 antibody, ARL1_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ARL1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200-1:2000
Purification method Purified by affinity chromatography


Target

Target Name ARL1
SwissProt ID Link P40616
Function GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.
Subcellular Location Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue Specificity Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney. Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Subunit Structure The GTP-bound form interacts with GOLGA1. The GTP-bound form interacts with GOLGA4 and RGPD8. The GTP-bound form directly interacts with ARFIP2; this interaction leads to a > 4-fold increase in the amount of bound GTP at steady state level. Binds to SCOC, preferentially in its GTP-bound form. May interact with UNC119.
Sequence Similarities Belongs to the small GTPase superfamily. Arf family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.