Anti-ARL13B antibody (AA33915)

$287.00


Alternative names ADP-ribosylation factor-like protein 13B, ADP-ribosylation factor-like protein 2-like 1, ARL2-like protein 1, ARL13B, ARL2L1, AR13B_HUMAN
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IP, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ARL13B antibody (AA33915)
Catalog number AA33915
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names ADP-ribosylation factor-like protein 13B antibody, ADP-ribosylation factor-like protein 2-like 1 antibody, ARL2-like protein 1 antibody, ARL13B antibody, ARL2L1 antibody, AR13B_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ARL13B
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500-1:2000 IP 1:20-1:50 IHC 1:50-1:200 IF 1:50-1:100
Purification method Purified by affinity chromatography


Target

Target Name ARL13B
SwissProt ID Link Q3SXY8
Function Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidences are required to confirm these data.
Subcellular Location Cell projection, cilium membrane; Lipid-anchor. Associates to the cilium membrane via palmitoylation. Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone.
Involvement in Disease Joubert syndrome 8: A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices . Additional variable features include retinal dystrophy and renal disease. The disease is caused by mutations affecting the gene represented in this entry.
Post-Translational Modification Sumoylation is required for PKD2 entry into cilium.
Subunit Structure Monomer. Interacts with PIFO. Interacts with IFT complex B components IFT46 and IFT74.
Sequence Similarities Belongs to the small GTPase superfamily. Arf family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.