Anti-ARIH2 antibody (AA39593)

$187.00


Alternative names E3 ubiquitin-protein ligase ARIH2, ARI-2, Protein ariadne-2 homolog, EC 6.3.2.-, Triad1 protein, ARIH2, ARI2, TRIAD1, HT005, ARI2_HUMAN, O95376, 10425
Source 493
Species Reactivity Human, Mouse
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ARIH2 antibody (AA39593)
Catalog number AA39593
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names E3 ubiquitin-protein ligase ARIH2 antibody, ARI-2 antibody, Protein ariadne-2 homolog antibody, EC 6.3.2.- antibody, Triad1 protein antibody, ARIH2 antibody, ARI2 antibody, TRIAD1 antibody, HT005 antibody, ARI2_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ARIH2
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ARIH2
SwissProt ID Link O95376
Function E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.
Subcellular Location Nucleus. Cytoplasm.
Post-Translational Modification Ubiquitinated. Ubiquitination promotes proteasomal degradation.
Tissue Specificity Widely expressed with higher expression in granulocytes.
Subunit Structure Interacts (via RING-type 1) with UBE2L3. Interacts (via RING-type 2) with UBE2N. Interacts (via RING-type 2) with GFI1B. Interacts with GFI1; prevents its ubiquitination and proteasomal degradation.
Sequence Similarities Belongs to the RBR family. Ariadne subfamily. Contains 1 IBR-type zinc finger. Contains 2 RING-type zinc fingers.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.