Anti-Apolipoprotein B antibody [clone 4B6/D4] (AA24083)


Alternative names Apolipoprotein B-100, Apo B-100, APOB, APOB_HUMAN, P04114, 338
Source 4563
Species Reactivity Human
Applications FC, IF/ICC, WB
Host Murine
Class Monoclonal
Conjugated Unconjugated


Product name Anti-Apolipoprotein B antibody [clone 4B6/D4] (AA24083)
Catalog number AA24084
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Apolipoprotein B-100 antibody, Apo B-100 antibody, APOB antibody, APOB_HUMAN antibody

Biological Information

Immunogen Recombinant protein of human APOB
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 ICC 1:500 - 1:1000 FC 1:50 - 1:200
Clone 4B6/D4
Purification method Purified by affinity chromatography


Target Name Apolipoprotein B
SwissProt ID Link P04114
Function Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
Subcellular Location Cytoplasm. Secreted.
Involvement in Disease Hypobetalipoproteinemia, familial, 1: A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. The disease is caused by mutations affecting the gene represented in this entry. Most cases of FHBL1 result from nonsense mutations in the APOB gene that lead to a premature stop codon, which generate prematurely truncated apo B protein products: Dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease . The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. The disease is caused by mutations affecting the gene represented in this entry. Defects in APOB associated with defects in other genes can contribute to hypocholesterolemia.
Post-Translational Modification Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.
Subunit Structure Interacts with PCSK9.
Sequence Similarities Contains 1 vitellogenin domain.

Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3

Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.