Anti-Apolipoprotein A V antibody [clone 7C8/D7] (AA24239)

$431.00


Alternative names Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3, APOA5, RAP3, UNQ411/PRO773, APOA5_HUMAN, Q6Q788, 116519
Source 366
Species Reactivity Human
Applications IF/ICC, WB
Host Murine
Class Monoclonal
Conjugated Unconjugated


Description

Product name Anti-Apolipoprotein A V antibody [clone 7C8/D7] (AA24239)
Catalog number AA24240
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Apolipoprotein A-V antibody, Apo-AV antibody, ApoA-V antibody, Apolipoprotein A5 antibody, Regeneration-associated protein 3 antibody, APOA5 antibody, RAP3 antibody, UNQ411/PRO773 antibody, APOA5_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human APOA5
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 ICC 1:200 - 1:1000
Clone 7C8/D7
Purification method Purified by affinity chromatography


Target

Target Name Apolipoprotein A V
SwissProt ID Link Q6Q788
Function Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
Subcellular Location Secreted.
Involvement in Disease Hypertriglyceridemia, familial: A common inherited disorder in which the concentration of very low density lipoprotein: Characterized by increased amounts of chylomicrons and very low density lipoprotein and decreased low density lipoprotein and high density lipoprotein in the plasma after a fast. Numerous conditions cause this phenotype, including insulin-dependent diabetes mellitus, contraceptive steroids, alcohol abuse, and glycogen storage disease type 1A . The disease is caused by mutations affecting the gene represented in this entry.
Post-Translational Modification Phosphorylation sites are present in the extracellular medium.
Tissue Specificity Liver and plasma.
Subunit Structure Interacts with GPIHBP1.
Sequence Similarities Belongs to the apolipoprotein A1/A4/E family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.