Anti-APOBEC3C antibody (AA35624)

$187.00


Alternative names DNA dC->dU-editing enzyme APOBEC-3C, A3C, EC 3.5.4.-, APOBEC1-like, Phorbolin I, APOBEC3C, APOBEC1L, PBI, ABC3C_HUMAN, Q9NRW3, 27350
Source 190
Species Reactivity Human
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-APOBEC3C antibody (AA35624)
Catalog number AA35624
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names DNA dC->dU-editing enzyme APOBEC-3C antibody, A3C antibody, EC 3.5.4.- antibody, APOBEC1-like antibody, Phorbolin I antibody, APOBEC3C antibody, APOBEC1L antibody, PBI antibody, ABC3C_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human APOBEC3C
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name APOBEC3C
SwissProt ID Link Q9NRW3
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Subcellular Location Nucleus. Cytoplasm.
Tissue Specificity Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary.
Subunit Structure Homodimer. Interacts with human foamy virus protein Bet; this interaction does not induce APOBEC3C degradation, but prevents dimerization and incorporation into virion of the latter. Interacts with TRIB3 and AGO2.
Sequence Similarities Belongs to the cytidine and deoxycytidylate deaminase family. Contains 1 CMP/dCMP-type deaminase domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.