Anti-APLP2 antibody (AA34509)

$187.00


Alternative names Amyloid-like protein 2, APLP-2, APPH, Amyloid protein homolog, CDEI box-binding protein, CDEBP, APLP2, APPL2, APLP2_HUMAN, Q06481, 334
Source 763
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-APLP2 antibody (AA34509)
Catalog number AA34509
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Amyloid-like protein 2 antibody, APLP-2 antibody, APPH antibody, Amyloid protein homolog antibody, CDEI box-binding protein antibody, CDEBP antibody, APLP2 antibody, APPL2 antibody, APLP2_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human APLP2
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name APLP2
SwissProt ID Link Q06481
Function May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.
Subcellular Location Cell membrane; Single-pass type I membrane protein. Nucleus.
Post-Translational Modification The BPTI/Kunitz inhibitor domain is O-glycosylated.
Tissue Specificity Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
Subunit Structure Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif.
Sequence Similarities Belongs to the APP family. Contains 1 BPTI/Kunitz inhibitor domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.