Anti-APLP1 antibody (AA26996)

$187.00


Alternative names Amyloid-like protein 1, APLP, APLP-1, APLP1, APLP1_HUMAN, P51693, 333
Source 650
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-APLP1 antibody (AA26996)
Catalog number AA26996
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Amyloid-like protein 1 antibody, APLP antibody, APLP-1 antibody, APLP1 antibody, APLP1_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human APLP1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:20 - 1:50
Purification method Purified by affinity chromatography


Target

Target Name APLP1
SwissProt ID Link P51693
Function May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Subcellular Location Cell membrane; Single-pass type I membrane protein.; C30: Cytoplasm. C-terminally processed in the Golgi complex.
Post-Translational Modification Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.
Tissue Specificity Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
Subunit Structure Monomer and homodimer. Heparin binding promotes homodimerization. Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB and APBA family members, MAPK8IP1 and Dab1. Binding to Dab1 inhibits its serine phosphorylation. Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts (via NPXY motif) with DAB1.
Sequence Similarities Belongs to the APP family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.