Anti-APIP antibody (AA38861)

$187.00


Alternative names Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase, EC 4.2.1.109, APAF1-interacting protein, hAPIP, APIP, CGI-29, MTNB_HUMAN, Q96GX9, 51074
Source 242
Species Reactivity Human
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-APIP antibody (AA38861)
Catalog number AA38861
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Methylthioribulose-1-phosphate dehydratase antibody, MTRu-1-P dehydratase antibody, EC 4.2.1.109 antibody, APAF1-interacting protein antibody, hAPIP antibody, APIP antibody, CGI-29 antibody, MTNB_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human APIP
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name APIP
SwissProt ID Link Q96GX9
Function Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
Subcellular Location Cytoplasm.
Tissue Specificity Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.
Subunit Structure Interacts with APAF1. May interact with CASP1.
Sequence Similarities Belongs to the aldolase class II family. MtnB subfamily.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.