Anti-AOX1 antibody (AA29522)

$287.00


Alternative names Aldehyde oxidase, EC 1.2.3.1, Aldehyde oxidase 1, Azaheterocycle hydroxylase, EC 1.17.3.-, AOX1, AO, AOXA_HUMAN
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-AOX1 antibody (AA29522)
Catalog number AA29522
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Aldehyde oxidase antibody, EC 1.2.3.1 antibody, Aldehyde oxidase 1 antibody, Azaheterocycle hydroxylase antibody, EC 1.17.3.- antibody, AOX1 antibody, AO antibody, AOXA_HUMAN antibody


Biological Information

Immunogen Synthetic peptide of human AOX1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Purification method Purified by affinity chromatography


Target

Target Name AOX1
SwissProt ID Link Q06278
Function Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
Subcellular Location Cytoplasm.
Tissue Specificity Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level).
Subunit Structure Homodimer.
Sequence Similarities Belongs to the xanthine dehydrogenase family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 FAD-binding PCMH-type domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.