|SwissProt ID Link
||Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.
||Cytoplasm.; Isoform 2: Nucleus.; Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner.; Isoform 4: Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; Isoform 6: Nucleus.
||Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage.
||Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
||Isoform 3 interacts with DLG4. Interacts with EPHA8. Isoform 2 interacts with COIL. Isoform 4 interacts with APP and EPHA8. Isoform 6 interacts with EPHA8.
||Contains 7 ANK repeats.
Contains 1 PID domain.
Contains 2 SAM (sterile alpha motif) domains.