Anti-ANKS1B antibody (AA40939)

$187.00


Alternative names Ankyrin repeat and sterile alpha motif domain-containing protein 1B, Amyloid-beta protein intracellular domain-associated protein 1, AIDA-1, E2A-PBX1-associated protein, EB-1, ANKS1B, ANS1B_HUMAN, Q7Z6G8, 56899
Source 1248?510?
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ANKS1B antibody (AA40939)
Catalog number AA40939
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Ankyrin repeat and sterile alpha motif domain-containing protein 1B antibody, Amyloid-beta protein intracellular domain-associated protein 1 antibody, AIDA-1 antibody, E2A-PBX1-associated protein antibody, EB-1 antibody, ANKS1B antibody, ANS1B_HUMAN antibody


Biological Information

Concentration 1 mg/ml
Isotype IgG
Purification method Purified by affinity chromatography


Target

Target Name ANKS1B
SwissProt ID Link Q7Z6G8
Function Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.
Subcellular Location Cytoplasm.; Isoform 2: Nucleus.; Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner.; Isoform 4: Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; Isoform 6: Nucleus.
Post-Translational Modification Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage.
Tissue Specificity Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
Subunit Structure Isoform 3 interacts with DLG4. Interacts with EPHA8. Isoform 2 interacts with COIL. Isoform 4 interacts with APP and EPHA8. Isoform 6 interacts with EPHA8.
Sequence Similarities Contains 7 ANK repeats. Contains 1 PID domain. Contains 2 SAM (sterile alpha motif) domains.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 C. Avoid multiple freeze/thaw cycles.