Anti-ANKRD2 antibody (AA32366)

$287.00


Alternative names Ankyrin repeat domain-containing protein 2, Skeletal muscle ankyrin repeat protein, hArpp, ANKRD2, ARPP, ANKR2_HUMAN
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ANKRD2 antibody (AA32366)
Catalog number AA32366
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Ankyrin repeat domain-containing protein 2 antibody, Skeletal muscle ankyrin repeat protein antibody, hArpp antibody, ANKRD2 antibody, ARPP antibody, ANKR2_HUMAN antibody


Biological Information

Concentration 1 mg/ml
Isotype IgG
Purification method Purified by affinity chromatography


Target

Target Name ANKRD2
SwissProt ID Link Q9GZV1
Function Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.
Subcellular Location Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
Post-Translational Modification Phosphorylation at Ser-99 by PKB/AKT2 in response to oxidative stress induces translocation to the nucleus and negatively regulates myoblast differentiation.
Tissue Specificity Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level).
Subunit Structure Interacts with ID3; both proteins cooperate in myoblast differentiation. Interacts with TTN/titin. Interacts (via ANK repeats) with TCAP; the interaction is direct. Interacts with TJP1 (via PDZ domains). Interacts with PML; the interaction is direct. Interacts with p53/TP53. Interacts with YBX1. Interacts with AKT2.
Sequence Similarities Contains 5 ANK repeats.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.