Anti-ANGPTL4 antibody (AA25580)

$187.00


Alternative names Angiopoietin-related protein 4, Angiopoietin-like protein 4, Hepatic fibrinogen/angiopoietin-related protein, HFARP, ANGPTL4, ARP4, PGAR, PP1158, PSEC0166, UNQ171/PRO197, ANGL4_HUMAN
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IHC, WB
Host Rabbit
Conjugated Unconjugated


Description

Product name Anti-ANGPTL4 antibody (AA25580)
Catalog number AA25580
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Angiopoietin-related protein 4 antibody, Angiopoietin-like protein 4 antibody, Hepatic fibrinogen/angiopoietin-related protein antibody, HFARP antibody, ANGPTL4 antibody, ARP4 antibody, PGAR antibody, PP1158 antibody, PSEC0166 antibody, UNQ171/PRO197 antibody, ANGL4_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ANGPTL4
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ANGPTL4
SwissProt ID Link Q9BY76
Function Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
Subcellular Location Secreted. Secreted, extracellular space, extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
Post-Translational Modification N-glycosylated.
Tissue Specificity Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
Subunit Structure Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix.
Sequence Similarities Contains 1 fibrinogen C-terminal domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.