Anti-Angiopoietin-2 antibody (AA22991)

$187.00


Alternative names Angiopoietin-2, ANG-2, ANGPT2, ANGP2_HUMAN
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IHC, WB
Host Rabbit
Conjugated Unconjugated


Description

Product name Anti-Angiopoietin-2 antibody (AA22991)
Catalog number AA22991
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Angiopoietin-2 antibody, ANG-2 antibody, ANGPT2 antibody, ANGP2_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ANGPT2
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name Angiopoietin-2
SwissProt ID Link O15123
Function Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Subcellular Location Secreted.
Subunit Structure Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.
Sequence Similarities Contains 1 fibrinogen C-terminal domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.