Anti-ALKBH7 antibody (AA26387)

$287.00


Alternative names Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial, EC 1.14.11.-, Alkylated DNA repair protein alkB homolog 7, Spermatogenesis cell proliferation-related protein, Spermatogenesis-associated protein 11, ALKBH7, ABH7, SPATA11, UNQ6002/PRO34564, ALKB7_HUMAN, Q9BT30, 84266
Source 221
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ALKBH7 antibody (AA26387)
Catalog number AA26387
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial antibody, EC 1.14.11.- antibody, Alkylated DNA repair protein alkB homolog 7 antibody, Spermatogenesis cell proliferation-related protein antibody, Spermatogenesis-associated protein 11 antibody, ALKBH7 antibody, ABH7 antibody, SPATA11 antibody, UNQ6002/PRO34564 antibody, ALKB7_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ALKBH7
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ALKBH7
SwissProt ID Link Q9BT30
Function May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism.
Subcellular Location Mitochondrion matrix.
Tissue Specificity Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
Subunit Structure Monomer.
Sequence Similarities Belongs to the alkB family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.