Anti-ALKBH4 antibody (AA40915)

$187.00


Alternative names Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4, EC 1.14.11.-, Alkylated DNA repair protein alkB homolog 4, ALKBH4, ABH4, ALKB4_HUMAN, Q9NXW9, 54784
Source 302
Species Reactivity Human
Applications WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ALKBH4 antibody (AA40915)
Catalog number AA40915
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 antibody, EC 1.14.11.- antibody, Alkylated DNA repair protein alkB homolog 4 antibody, ALKBH4 antibody, ABH4 antibody, ALKB4_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ALKBH4
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IF 1:50 - 1:100
Purification method Purified by affinity chromatography


Target

Target Name ALKBH4
SwissProt ID Link Q9NXW9
Function Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation.
Subcellular Location Cytoplasm. Nucleus. Midbody. Associates with the contractile ring and midbody.
Tissue Specificity Widely expressed, with highest expression in pancreas, ovary and spleen.
Subunit Structure Interacts with ZFHX3, MLLT3, MLLT1, HSF4, EP300, TES, EIF3C, MTMR6 and PSMA6.
Sequence Similarities Belongs to the alkB family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.