Anti-ALDH4A1 antibody (AA26927)

$187.00


Alternative names Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, P5C dehydrogenase, EC 1.2.1.88, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase, ALDH4A1, ALDH4, P5CDH, AL4A1_HUMAN, P30038, 8659
Source 563
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ALDH4A1 antibody (AA26927)
Catalog number AA26927
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial antibody, P5C dehydrogenase antibody, EC 1.2.1.88 antibody, Aldehyde dehydrogenase family 4 member A1 antibody, L-glutamate gamma-semialdehyde dehydrogenase antibody, ALDH4A1 antibody, ALDH4 antibody, P5CDH antibody, AL4A1_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ALDH4A1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ALDH4A1
SwissProt ID Link P30038
Function Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Subcellular Location Mitochondrion matrix.
Involvement in Disease Hyperprolinemia 2: An inborn error of proline metabolism resulting in elevated plasma levels of proline and delta-1-pyrroline-5-carboxylate . The condition is considered to be benign, but affected individuals can exhibit neurological manifestations that vary in severity. Clinical signs include seizures, intellectual deficit and mild developmental delay. The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.
Subunit Structure Homodimer.
Sequence Similarities Belongs to the aldehyde dehydrogenase family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.