Anti-ALDH18A1 antibody (AA35716)

$287.00


Alternative names Delta-1-pyrroline-5-carboxylate synthase, P5CS, Aldehyde dehydrogenase family 18 member A1, ALDH18A1, GSAS, PYCS, P5CS_HUMAN
Species Reactivity Human, Mouse, Rat
Applications IP, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ALDH18A1 antibody (AA35716)
Catalog number AA35716
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Delta-1-pyrroline-5-carboxylate synthase antibody, P5CS antibody, Aldehyde dehydrogenase family 18 member A1 antibody, ALDH18A1 antibody, GSAS antibody, PYCS antibody, P5CS_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ALDH18A1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IP 1:20 - 1:50
Purification method Purified by affinity chromatography


Target

Target Name ALDH18A1
SwissProt ID Link P54886
Function Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.
Subcellular Location Mitochondrion inner membrane.
Involvement in Disease Cutis laxa, autosomal recessive, 3A: A syndrome characterized by facial dysmorphism with a progeroid appearance, large and late-closing fontanel, cutis laxa, joint hyperlaxity, athetoid movements and hyperreflexia, pre- and postnatal growth retardation, intellectual deficit, developmental delay, and ophthalmologic abnormalities. The disease is caused by mutations affecting the gene represented in this entry.
Sequence Similarities In the N-terminal section; belongs to the glutamate 5-kinase family. In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.