|SwissProt ID Link
||Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
|Involvement in Disease
||Hyperthyroxinemia, familial dysalbuminemic: A disorder characterized by abnormally elevated levels of total serum thyroxine: A rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. Affected individuals manifest mild edema, hypotension, fatigue, and, occasionally, lower body lipodystrophy
. The most common biochemical finding is hyperlipidemia, with a significant increase in the total and LDL cholesterol concentrations, but normal concentrations of HDL cholesterol and triglycerides. The disease is caused by mutations affecting the gene represented in this entry.
||Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.Glycated in diabetic patients.Phosphorylation sites are present in the extracellular medium.Acetylated on Lys-223 by acetylsalicylic acid.
||Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains.