Anti-AKR7A2 antibody (AA23915)

$187.00


Alternative names Aflatoxin B1 aldehyde reductase member 2, EC 1.1.1.n11, AFB1 aldehyde reductase 1, AFB1-AR 1, Aldoketoreductase 7, Succinic semialdehyde reductase, SSA reductase, AKR7A2, AFAR, AFAR1, AKR7, ARK72_HUMAN, O43488, 8574
Source 359
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-AKR7A2 antibody (AA23915)
Catalog number AA23915
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Aflatoxin B1 aldehyde reductase member 2 antibody, EC 1.1.1.n11 antibody, AFB1 aldehyde reductase 1 antibody, AFB1-AR 1 antibody, Aldoketoreductase 7 antibody, Succinic semialdehyde reductase antibody, SSA reductase antibody, AKR7A2 antibody, AFAR antibody, AFAR1 antibody, AKR7 antibody, ARK72_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human AKR7A2
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Purification method Purified by affinity chromatography


Target

Target Name AKR7A2
SwissProt ID Link O43488
Function Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Subcellular Location Golgi apparatus. Cytoplasm.
Tissue Specificity Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.
Subunit Structure Homodimer.
Sequence Similarities Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.