Anti-AKR1A1 antibody (AA23465)

$187.00


Alternative names Alcohol dehydrogenase, EC 1.1.1.2, Aldehyde reductase, Aldo-keto reductase family 1 member A1, AKR1A1, ALDR1, ALR, AK1A1_HUMAN, P14550, 10327
Source 325
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-AKR1A1 antibody (AA23465)
Catalog number AA23465
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Alcohol dehydrogenase antibody, EC 1.1.1.2 antibody, Aldehyde reductase antibody, Aldo-keto reductase family 1 member A1 antibody, AKR1A1 antibody, ALDR1 antibody, ALR antibody, AK1A1_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human AKR1A1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Purification method Purified by affinity chromatography


Target

Target Name AKR1A1
SwissProt ID Link P14550
Function Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Tissue Specificity Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
Subunit Structure Monomer.
Sequence Similarities Belongs to the aldo/keto reductase family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.