Anti-AKAP8L antibody (AA28151)

$187.00


Alternative names A-kinase anchor protein 8-like, AKAP8-like protein, Helicase A-binding protein 95, HAP95, Homologous to AKAP95 protein, HA95, Neighbor of A-kinase-anchoring protein 95, Neighbor of AKAP95, AKAP8L, NAKAP, NAKAP95, HRIHFB2018, AKP8L_HUMAN, Q9ULX6, 26993
Source 646
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-AKAP8L antibody (AA28151)
Catalog number AA28151
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names A-kinase anchor protein 8-like antibody, AKAP8-like protein antibody, Helicase A-binding protein 95 antibody, HAP95 antibody, Homologous to AKAP95 protein antibody, HA95 antibody, Neighbor of A-kinase-anchoring protein 95 antibody, Neighbor of AKAP95 antibody, AKAP8L antibody, NAKAP antibody, NAKAP95 antibody, HRIHFB2018 antibody, AKP8L_HUMAN antibody


Biological Information

Concentration 1 mg/ml
Isotype IgG
Purification method Purified by affinity chromatography


Target

Target Name AKAP8L
SwissProt ID Link Q9ULX6
Function Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta.
Subcellular Location Nucleus matrix. Cytoplasm. Colocalizes with PRPF40A in the nuclear matrix. Nuclear at steady state but shuttles between the nucleus and cytoplasm. Associated with the nuclear matrix.
Post-Translational Modification Phosphorylated on serine or threonine residues possibly by PKA.
Tissue Specificity Expressed in the brain cortex (at protein level).
Subunit Structure Interacts with PRPF40A. Binds to the C-terminal of RNA helicase A and to TMPO-beta. Interacts with RNF43.
Sequence Similarities Belongs to the AKAP95 family. Contains 2 C2H2 AKAP95-type zinc fingers.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 C. Avoid multiple freeze/thaw cycles.