Anti-AKAP13 antibody (AA40235)

$187.00


Alternative names A-kinase anchor protein 13, AKAP-13, AKAP-Lbc, Breast cancer nuclear receptor-binding auxiliary protein, Guanine nucleotide exchange factor Lbc, Human thyroid-anchoring protein 31, Lymphoid blast crisis oncogene, LBC oncogene, Non-oncogenic Rho GTPase-specific GTP exchange factor, Protein kinase A-anchoring protein 13, PRKA13, p47, AKAP13, BRX, HT31, LBC, AKP13_HUMAN, Q12802, 11214
Source 2813?2817?
Species Reactivity Human
Applications WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-AKAP13 antibody (AA40235)
Catalog number AA40235
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names A-kinase anchor protein 13 antibody, AKAP-13 antibody, AKAP-Lbc antibody, Breast cancer nuclear receptor-binding auxiliary protein antibody, Guanine nucleotide exchange factor Lbc antibody, Human thyroid-anchoring protein 31 antibody, Lymphoid blast crisis oncogene antibody, LBC oncogene antibody, Non-oncogenic Rho GTPase-specific GTP exchange factor antibody, Protein kinase A-anchoring protein 13 antibody, PRKA13 antibody, p47 antibody, AKAP13 antibody, BRX antibody, HT31 antibody, LBC antibody, AKP13_HUMAN antibody


Biological Information

Concentration 1 mg/ml
Isotype IgG
Purification method Purified by affinity chromatography


Target

Target Name AKAP13
SwissProt ID Link Q12802
Function Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions.
Subcellular Location Cytoplasm. Nucleus. Membrane.
Tissue Specificity Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle.
Subunit Structure Binds cAMP-dependent protein kinase (PKA) and to the RII-alpha regulatory subunit of PKA. Interacts with ESR1, ESR2, THRA, PPARA, RHOA and NME2.
Sequence Similarities Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 phorbol-ester/DAG-type zinc finger.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 C. Avoid multiple freeze/thaw cycles.