Anti-AIM2 antibody (AA28859)

$287.00


Alternative names Interferon-inducible protein AIM2, Absent in melanoma 2, AIM2, AIM2_HUMAN, O14862, 9447
Source 343
Species Reactivity Human
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-AIM2 antibody (AA28859)
Catalog number AA28859
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Interferon-inducible protein AIM2 antibody, Absent in melanoma 2 antibody, AIM2 antibody, AIM2_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human AIM2
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name AIM2
SwissProt ID Link O14862
Function Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Subcellular Location Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Tissue Specificity Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.
Subunit Structure Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as oligomerization platform. Component of the AIM2 inflammasome. Interacts with PYCARD, IFI16, EIF2AK2/PKR and MAPRE1.
Sequence Similarities Belongs to the HIN-200 family. Contains 1 DAPIN domain. Contains 1 HIN-200 domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.