Anti-AIF1 antibody (AA34709)

$287.00


Alternative names Allograft inflammatory factor 1, AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1, AIF1, G1, IBA1, AIF1_HUMAN
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IP, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-AIF1 antibody (AA34709)
Catalog number AA34709
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Allograft inflammatory factor 1 antibody, AIF-1 antibody, Ionized calcium-binding adapter molecule 1 antibody, Protein G1 antibody, AIF1 antibody, G1 antibody, IBA1 antibody, AIF1_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human AIF1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:100
Purification method Purified by affinity chromatography


Target

Target Name AIF1
SwissProt ID Link P55008
Function Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Subcellular Location Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
Post-Translational Modification Phosphorylated on serine residues.
Tissue Specificity Detected in T-lymphocytes and peripheral blood mononuclear cells.
Subunit Structure Homodimer (Potential). Monomer. Interacts with LCP1.
Sequence Similarities Contains 2 EF-hand domains.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.