Anti-AGER antibody (AA24185)

$187.00


Alternative names Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER, RAGE, RAGE_HUMAN
Species Reactivity Human
Applications IHC, WB
Host Rabbit
Conjugated Unconjugated


Description

Product name Anti-AGER antibody (AA24185)
Catalog number AA24185
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Advanced glycosylation end product-specific receptor antibody, Receptor for advanced glycosylation end products antibody, AGER antibody, RAGE antibody, RAGE_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human AGER
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name AGER
SwissProt ID Link Q15109
Function Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Subcellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 10: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Endothelial cells.
Subunit Structure Interacts with S100A1 and APP. Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.
Sequence Similarities Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.