Anti-ADI1 antibody (AA32924)

$287.00


Alternative names 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, EC 1.13.11.54, Acireductone dioxygenase, Fe(2+)-requiring), ARD, Fe-ARD, Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1, MTCBP-1, Submergence-induced protein-like factor, Sip-L, ADI1, MTCBP1, HMFT1638, MTND_HUMAN, Q9BV57, 55256
Source 179
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ADI1 antibody (AA32924)
Catalog number AA32924
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase antibody, EC 1.13.11.54 antibody, Acireductone dioxygenase antibody, Fe(2+)-requiring) antibody, ARD antibody, Fe-ARD antibody, Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1 antibody, MTCBP-1 antibody, Submergence-induced protein-like factor antibody, Sip-L antibody, ADI1 antibody, MTCBP1 antibody, HMFT1638 antibody, MTND_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ADI1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200-1:2000 IHC 1:50-1:200
Purification method Purified by affinity chromatography


Target

Target Name ADI1
SwissProt ID Link Q9BV57
Function Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Subcellular Location Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Localizes to the plasma membrane when complexed to MMP14.
Tissue Specificity Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.
Subunit Structure Monomer. Interacts with MMP14.
Sequence Similarities Belongs to the acireductone dioxygenase (ARD) family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.